Process of producing a medicament.



" Mm W W. D. NEEL. PROCESS OF PRODUCING A MBDIGAMENT. APPLICATION FILEDJULY 5, 1902.

925,590. I Patented June 22, 1909.

UNITED STATES PATENT OFFICE.

WILLIAM D. NEEL, OF CHICAGO, ILLINOIS, ASSIGNOR, BY DIRECT AND lVlESNEASSIGNMENTS, 4

OF ONE-HALF TO THE OXOLINE COMPANY, OF JERSEY CITY, NEW JERSEY, ACORPORA- TION OF NEW JERSEY, AND ONE-HALF TO NEEL-ARMSTRONG 00., ACORPORATION OF MAINE.

-PROCESS OF PRODUCING A MEDIGAMENT.

Specification of Letters Patent. Application filed July 5, 1902. SerialNo. 114,365.

Patented June 22, 1909.

cago, in the county of Cook and State of Illinois, have invented acertain new and useful Improvement in Processes of ProducingMedicaments, of which the following is a specification.

. My invention relates to anew and improved process for producing a newand improved medicament.

My invention is illustrated in the accompanying drawings, wherein Figure1 is a view showing one arrangement for'carrylng my process mto effect;

Fig. 2 shows a modified construction.

My present process relates to the production 0 a medlcament particularlyadapted to diseases of the blood and the respiratory organs, suchasconsumption, asthma, syphozone passes through this oil.

. needles, oil of jum er ment ofcarrying my process into eflect.

to consist in bringing an active oxidizing agent into proximity to orin'contact with a hydrocarbon oil of the ter ene group, the resultantproduct being a ministered to the patient in an inhalable form.

Referring now to the drawing, in Fig. 1 I have shown one ap aratus forcarrying my process into efiect. n this apparatus, I provide a device Afor making or generating ozone. This device may be of any of thesuitable constructions for this urpose which will generate sufiicientozone, or unless sufiicient ozone is enerated no useful results can besecured. onnected with the ozone generator is a tube or rece tacle B,preferably of glass and also preferab y bent so as to form a tra asindicated. In this tubeI place an oil that is a hydrocarbon oil of theterpene group, and the parts are so arranged that the The resultantproduct is then Ipassed through a suitable confining device and isadministered to'the patient, the patient inhaling such resultant roduct.I have found that various oils may ensed in connection with the ozone,such for example aseucaly tus oil, oil of ine erries, and the 'ke thatis a hy'drocar'. on or volatile oil of the ter ene gI'OliP.

. n Fig. 2, have shown a .diflerent arrangIen this construction, theozone generator A is perimente connected to a tube F, which is closed atthe end, but which has along a portion of its length a series ofopenings F The tube is contained in a vessel which contains the oil. Thetube D is connected with this vessel so as to conduct the resultantproduct to. the point desired. The ozone ,in passing through theopenings F is thus brought mto intimate contact with the oil and thedirection of the movement of the ozone is such as to prevent the oilfrom being forced out intothe tube D.

Ihave found that ozone cannot well be administered to the patients,because of the fact that it is an irritant and causes violent fits ofcoughing when administered, (particul'arly to patients afllicted withlung iseases. It was in the attempt to use ozone that I discovered Inpresent invention. I have exwith this medicament, my experimentsextending over a long period of time, and have administered it tonumerous people and noted the effect it produced and have watched theseeople to see if the effect was ermanent. experiments covering this ongperiod have convinced me of its eflicacy incurin consumption, asthma andother diseases of t e respiratory organs, as well as diseases of theblood. Ifind that this medicament, when roperly administered, increasesthe red bloocFcorpuscles and hemoglobin and has a general beneficialaction upon the system. This medicament when inhaled heals suppurativeprocesses and renders the tissues unsuitable for the propagation ofgerms'm such diseases as consumption and syphilis and stops its proress, thus curing the patients. ment does not have the effect upon thepatient of ozone and I have subjected it to room, or I may confine it inreceptacles which may be. sent to ,the patient, or I may use variousother methods and arrangements. I therefore do not limit myself to theapparatus and method describe This resu tant product or medica- I may,for example,

I have shown my afp aratus diagrammatically for purposes 0 filustration.Any of the OllS belongm to the class herein described may be use aloneor two or more of such oils ma be mixed. It is of course evident that alsuch details will de end upon the conditions to be met and I of coursedo not limit myself in any such particular.

I prefer to rovide' some means for producing a circulatlon ,through'theozone generator. Any desired means for this purpose may be used and Ihaveshown for purposes of illustration a fan I. This fan, or as it isperhaps more properly termed flower, raises the ozone and air to apressure superior to the surrounding atmosphere. This pressure, can, ofcourse, be regulated by the speed of the blower. The ozone generator, asbefore stated, may be of any suitable construction, such for exam 1e asthat illustrated in my prior patent 0. 642,663.

I refer to raise the temperature of the euca y tus or other volatile oilor material throu h which the ozone is passed, say above 70. While thisis notnecessary, it is yet a convenience, and this temperature may besecured in any desired way, as "by heating the material before it isplaced in the receptacle in which it is used, or after being placed. insuch receptacle, :or the heating,

effect may easily be produced. by simpl raising the temperature oftheroom in WhlO the device is used.

1. The rocess of producing terpene-peroxid, whic consists in bringinginto contact with a terpene hydrocarbon, in the absence of water, anoxidizin agent of sufficient chemical activity to OXldlZG thehydrocarbon water, ozone or ozonized air, and thereby" causin fumes ofthe as set orth.

4. The process of producing medicinal fumes for inhalation pur oseswhich consists peroxid to be evolve in forcmg ozone throug a hydrocarbonoil of the terpene grou in the absence of water. 5.- The process 0producing a medicament which consists in forming ozone and then brin ingsuch ozone into contact with euca y tus oil so as to produce fumes, saidfumes ormingthe medicament.

6. The process of producing a highly oxidizing vapor which consists inpassing ozone in contact with oil of eucalyptus at a pressure superiorto the surrounding atmosphere so as to cause vapor to be evolved:

7. The process of producing-a medicament which consists in heatin ahydrocarbon oil of the terpene group an bringing ozone into I contacttherewithcausing fumes of the medicament to be evolved.

Witnesses: HOMER L. Kaorr, FANNY' B. FAY.

WILLIAM DINE L.

